Fenestra VC

Description

Fenestra VC contrast agent is used for longitudinal vascular imaging small laboratory animals for research. It is a specialized version of Fenestra LC in which the surface of the lipid emulsion particles is modified with DSPE-PEG which blocks the interaction with APO-E thus enabling preclinical angiography by delaying the targeted uptake by hepatocytes of the lipid spheres. Like its liver-selective counterpart, Fenestra VC is eventually metabolized and eliminated through the hepatobiliary system enabling multiple injection longitudinal studies.

Properties

• 1,3-bis-[7-(3-amino-2,4,6-triiodophenyl)-heptanoyl]-2-oleoyl glycerol (DHOG) in a 20% (w/v) total triglyceride oil-in-water pegylated emulsion with 10% DHOG (nominal 50 mg I/mL)
• Under 200 nm particle size, 50 mg/ml Iodine concentration

Publications

75 articles

• Antitumorigenic and antiangiogenic efficacy of apatinib in liver cancer evaluated by multimodality molecular imaging. 2019, Exp. Mol. Med., Liang Q, Kong L, Du Y, Zhu X, Tian J. abstract  article
• In Vivo Detection and Measurement of Aortic Aneurysm and Dissection in Mouse Models Using Microcomputed Tomography with Contrast Agent. 2019, Contrast Media Mol Imaging, Zhu G, Sun H, Wang J, Zhao Z, Bao J, Feng R, Zhou J, Jing Z. abstract  article
• Micro-CT myelography using contrast-enhanced digital subtraction: feasibility and initial results in healthy rats. 2019, Neuroradiology, Zambrano-Rodríguez PC, Bolaños-Puchet S, Reyes-Alva HJ, García-Orozco LE, Romero-Piña ME, Martinez-Cruz A, Guízar-Sahagún G, Medina LA. abstract  article
• Sex-dependent differences in central artery haemodynamics in normal and fibulin-5 deficient mice: implications for ageing. 2019, Proc. Math. Phys. Eng. Sci., Cuomo F, Ferruzzi J, Agarwal P, Li C, Zhuang ZW, Humphrey JD, Figueroa CA. abstract  article
• Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of β-aminopropionitrile-induced Aortic Aneurysm and Dissection. 2018, J Vis Exp, Aicher BO, Mukhopadhyay S, Lu X, Muratoglu SC, Strickland DK, Ucuzian AA. abstract  article
• Notch3 as a novel therapeutic target in metastatic medullary thyroid cancer. 2018, Surgery, Lou I, Odorico S, Yu XM, Harrison A, Jaskula-Sztul R, Chen H. abstract  article
• Contrast-enhanced micro-CT imaging in murine carotid arteries: a new protocol for computing wall shear stress. 2016, Biomed Eng Online, Xing R, De Wilde D, McCann G, Ridwan Y, Schrauwen JT, van der Steen AF, Gijsen FJ, Van der Heiden K. abstract  article
• Development of a methodology for in vivo follow-up of hepatocellular carcinoma in hepatocyte specific Trim24-null mice treated with myo-inositol trispyrophosphate. 2016, J. Exp. Clin. Cancer Res., Ignat M, Akladios CY, Lindner V, Khetchoumian K, Teletin M, Muttter D, Aprahamian PM, Marescaux J. abstract  article
• Comparison of small animal CT contrast agents. 2016, Contrast Media Mol Imaging, Mannheim JG, Schlichthaerle T, Kuebler L, Quintanilla-Martinez L, Kohlhofer U, Kneilling M, Pichler BJ. abstract  article
• In vivo small animal micro-CT using nanoparticle contrast agents. 2015, Front Pharmacol, Ashton JR, West JL, Badea CT. abstract  article